ea0038p219 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015
Scotney Hannah
, Symonds Michael
, Law James
, Budge Helen
, Sharkey Don
, Manolopoulos Konstantinos
Brown adipose tissue (BAT) is present in small quantities in human adults (~100 g) and can have a significant influence on metabolism. This effect is mediated by rapid activation of the BAT specific uncoupling protein 1 (UCP1), following stimulation of β-adrenergic receptor (AR) by the sympathetic nervous system. AR agonists stimulate rodent BAT, but have so far provided inconsistent findings in humans when administered orally (Vosselman et al. 2012). Rapid activ...